A Systematic Review of Medical Cyclotron, Producing F-18 & FDG Radio Isotopes for Pet Scan Imaging

  Muhammad Shariq Khan,  Nemra Kanwal,  Hamda Rozeen

Alzheimer’s Disease is the most common form of dementia (memory loss). More than 5 million people are currently living with Alzheimer’s and experts predicts this number could be tripled by 2050. Early detection of AD through molecular imaging techniques will assist the development & the evolution of medication to slow down the progression of the disease & optimize patient care. The most commonly used medical imaging for diagnosing & guiding the treatment of Alzheimer’s disease is Positron Emission Tomography (PET) Scanning. PET scans are very useful diagnostic scans and are obtained through the use of neutron deficient radioisotopes. In order to emit positron, fluorine-18 (18F) isotope is prepared from water enriched with the 18O isotope using high energy protons by a cyclotron. A cyclotron is a particle accelerator. These particles are then focused onto a target O18 and the bombardment causes the production of the desired radioisotope i.e. F18. F-18 is then attached to a form of glucose called 2-deoxyglucose. This forms a radiolabeled pharmaceutical called 2-fluoro-2-deoxyglucose (FDG) and when given to a patient the body assumes it is glucose. Being radioactive, FDG assist in molecular imaging of the body. The purpose of this study is to present the systematic review of evidence based literature concerning the production of F18 labeled FDG Radioisotopes by medical Cyclotron.

Keywords- Cyclotron, Radio isotopes, Positron, Fluorodeoxyglucose (FDG)

Unique Identification Number - IJEDR1704099
Page Number(s) - 620-623
Pubished in - Volume 5 | Issue 4 | November 2017
DOI (Digital Object Identifier) -   
Publisher - IJEDR (ISSN - 2321-9939)

  Muhammad Shariq Khan,  Nemra Kanwal,  Hamda Rozeen,   "A Systematic Review of Medical Cyclotron, Producing F-18 & FDG Radio Isotopes for Pet Scan Imaging", International Journal of Engineering Development and Research (IJEDR), ISSN:2321-9939, Volume.5, Issue 4, pp.620-623, November 2017, Available at :http://www.ijedr.org/papers/IJEDR1704099.pdf