Co-crystallization an alternative modified technique for solubility enhancement
Miss. Pranali P. Hatwar,  Mr. Gajanan S. Hudekar,  Dr. Gajanan S. Sanap,  Mr. Gaurav G. Hudekar,  Rahul R. Pawar
Solubility refers to the process of a solid dissolving in a liquid phase to produce a homogeneous molecular dispersion, which is critical for therapeutic success. Despite their potential pharmacokinetic action, poor water solubility of medicines is a crucial factor in their successful commercial introduction. API and a stoichiometric amount of pharmaceutically approved co-crystal former make up co-crystals. The article provides a brief overview of co-crystallization, including how it differs from other states and why it is important as a substitute for salt production. The study also discusses the current FDA notice on co-crystallization guidance, as well as the various procedures for creating co-crystals. Which have been improved, emphasising their significance in the current trend of increasing solubility. Various examples of the co crystals which increases the properties of drugs.ie solubility, stability, bioavailability.
Keywords- co-crystal, solvent evaporation, solvent drop grinding, hot melt extrusion, high throughput co-crystallization, sonocrystallization
Cite this Article
Miss. Pranali P. Hatwar,  Mr. Gajanan S. Hudekar,  Dr. Gajanan S. Sanap,  Mr. Gaurav G. Hudekar,  Rahul R. Pawar,   "Co-crystallization an alternative modified technique for solubility enhancement"
, International Journal of Engineering Development and Research (IJEDR), ISSN:2321-9939, Volume.10, Issue 1, pp.63-70, March 2022, Available at :http://www.ijedr.org/papers/IJEDR2201012.pdf