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INTERNATIONAL JOURNAL OF ENGINEERING DEVELOPMENT AND RESEARCH
(International Peer Reviewed,Refereed, Indexed, Citation Open Access Journal)
ISSN: 2321-9939 | ESTD Year: 2013

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Paper Title
A New Method Development and Validation for Estimation of Prednisolone in Pharmaceutical Dosage Formulations by Reverse Phase High Performance Liquid Chromatography
Authors
  Chikkanna V,  Prabhakara S,  Hanumantha Rao H.M,  Sahajanand H

Abstract
An accurate, simple, rapid, precise and cost-effective reverse phase high performance liquid chromatographic method was developed and validated for the prednisolone in solid dosage formulation. The separation was achieved by YMC basic column (150mm × 4.6mm, 5μm particle size) using methanol and water (ratio 60:40) as a mobile phase at a flow rate of 1.0 mL/min. The retention time of Prednisolone was found to be 3.3 +/- 0.2 mins. The detection was monitored at 240 nm by using a PDA detector. The developed method was validated according to the international conference on Harmonization (ICH) guidelines Q2(R1) 2005. The linearity of prednisolone was in the range of 10 ppm to 150 ppm. The recovery of the drug was ranged from 99.69 to 101.23%. The percentage of RSD was found to be less than two. The proposed method is more specific with shorter run time and cost-effective, which can be used for the determination of prednisolone in the solid dosage form.

Keywords- Prednisolone, RP-HPLC, PDA, Retention time, Validation
Publication Details
Unique Identification Number - IJEDR2001049
Page Number(s) - 256-261
Pubished in - Volume 8 | Issue 1 | January 2020
DOI (Digital Object Identifier) -   
Publisher - IJEDR (ISSN - 2321-9939)
Cite this Article
  Chikkanna V,  Prabhakara S,  Hanumantha Rao H.M,  Sahajanand H,   "A New Method Development and Validation for Estimation of Prednisolone in Pharmaceutical Dosage Formulations by Reverse Phase High Performance Liquid Chromatography", International Journal of Engineering Development and Research (IJEDR), ISSN:2321-9939, Volume.8, Issue 1, pp.256-261, January 2020, Available at :http://www.ijedr.org/papers/IJEDR2001049.pdf
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